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The .45-60 Winchester is a centerfire rifle cartridge intended for 19th-century big-game hunting Nomenclature of the era indicated the .45-60 cartridge contained a 0.45-inch (11 mm) diameter bullet with 60 grains (3.9 g) of black powder. Winchester Repeating Arms Company shortened the .45-70 Government cartridge to operate through the Winchester Model 1876 rifle's lever-action.
The .45-60 and similarly short cartridges designed for the Model 1876 rifle faded into obsolescence as 20th-century hunters preferred more powerful smokeless powder loadings of cartridges designed for stronger rifles.